Local controlled drug delivery for prolonged pain relief in joints
Upon an intra-articular or intra-discal application, biomaterials enabling controlled release of anti-inflammatory medication harness inflammation and mitigate pain. Through a unique preclinical platform employing small animal models and ultimately the veterinary patients suffering from osteoarthritis or back pain, we have been able to develop these strategies.
To feed these strategies with the appropriate biomolecules, we employ developmental biology and the divergence seen within the canine species to identify and validate regenerative targets by means of “omics”. Within this context, we also study how joint distraction facilitates intrinsic cartilage repair.