We have an internship position available for a UU GSLS MSc student for their MSc research internship (6 to 9 months) for the NC-CHOICE project. In this research project, we aim to study the interaction between Lipid Nanoparticles (LNPs) and the extracellular matrix of the intervertebral disc (IVD) with the focus on the formation of biomolecular corona. We will also evaluate the effect of dNCM on the transfection efficiency of LNPs in healthy and degenerate conditions. Finaly, you will employ a magnetic separation method to identify which protein adsorb to the LNPs’ surface.
Used methods:
- Cell culture techniques
- LNPs preparation (microfluidic system NanoAssemblr)
- LNPs characterization techniques (DLS, ELS, RiboGreen and Cholesterol Assay)
- Confocal microscopy
- Biochemical assays
Supervisor: dr. Aida Moreira
Preferred start date: to be discussed
Duration: 6-9 months
Eligibility: students enrolled at the GSLS at Utrecht University. Especially suitable for students enrolled in the programs: Bio Inspired Innovation (BII), Drug Innovation (DI), or Regenerative Medicine and Technology (RMT). Students from other universities or research institutes who can compensate their benchfees are welcome to apply.
Interested? Fill in the form below: