Project description: we have an internship position available for a UU GSLS MSc student for their MSc research internship (6 to 9 months) for a project within the Ombion project and the VHH-MARS project. We have developed a model to culture murine whole knee joints ex vivo using a 3D-printed custom dynamic culture system. In this project you will look more into the application of the model to be used for various intra-articular therapies for osteoarthritis, from mRNA therapy using Lipid Nanoparticles (LNPs), to gene therapy with High-Capacity Adenovirus vectors (HCAds). We receive rat cadavers weekly, so the project is not limited to infrequent availability of cadaveric material. You will use the following techniques:
- Cadaver (rats/mice) dissection
- Tissue culture
- Biochemical assays
- Histology
- 3D printing of culture tools (FDM/SLA)
Supervisor: dr. Lizette Utomo
Preferred starting date: to be discussed, preferably mid/end november
Duration: 6 to 9 months
Eligibility: students enrolled at the GSLS at Utrecht University. Especially suitable for students enrolled in the programs: Regenerative Medicine and Technology (RMT), Biofabrication, Drug innovation, or Bio Inspired Innovation (BII). Students from other universities or research institutes who can compensate their benchfees are welcome to apply.
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