Osteoarthritis (OA) is a complex multifactorial joint disease characterized by chronic pain, articular cartilage degeneration, and low-grade, chronic inflammation. Current treatments such as NSAIDs and intra-articular steroid injections provide symptomatic relief but are associated with systemic side effects. Local administration of nucleic acid loaded delivery platforms could enhance therapeutic efficacy, minimizing off target effects.
Project description: we have an open internship position for an enthusiastic MSc student within the VHH-MARS project in which we aim to develop a drug delivery platform, guiding mRNA to inflamed joint cells. During this internship you will work on the development and evaluation of targeted lipid nanoparticle (LNP) systems. Focusing on targeting studies, including co-cultures and explant work, and VHH-conjugation strategies.
What you will experience:
- Primary cell & tissue isolation and culture
- Live-cell imaging techniques and data analysis
- Preparation, characterization and conjugation of Lipid Nanoparticles
- Flow cytometry
- Biochemical assays
Supervisor: Jordi Martens
Starting date: to be discussed, preferably around September
Duration: minimum of 6 and up to 12 months.
Eligibility: Master students enrolled at Utrecht University in the Master programs: Drug Innovation (DI), Bio Inspired Innovation (BII), Regenerative Medicine & Technology (RMT) have priority. All students and their program coordinators must sign an internship contract (UU template) prior to start of the internship.
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