New publication
New publication: Disc-Derived Induced Pluripotent Stem Cells and Environmental Cues for Nucleus Pulposus Regeneration
Congrats to Lisanne Laagland and colleagues for their latest paper where they explored an alternative for notochordal cells using human induced pluripotent stem cells (iPSC) by comparing cells derived from disc progenitor cells versus blood cells. By combining these cells with an instructive disc-derived matrix, the team achieved better differentiation into healthy, disc-repairing cells. The…
Read moreNew publication: High-intensity zones in dogs with lumbosacral intervertebral disc degeneration: insights from MRI and histopathological findings
A huge congratulations to PhD candidate Amir Kamali on his first published manuscript! Excitingly, this study is the first to document the presence of High Intensity Zones (HIZ) on both MRI and histology at the lumbosacral level in dogs with disc degeneration. This remarkable finding further strengthens the growing similarities between dog and human MRI…
Read moreNew publication: The Anti-Inflammatory Effects of Liraglutide in Equine Inflammatory Joint Models
Congrats to Ann-Sofie Scheike who published her paper on the effects of a glucagon-like peptide 1 receptor agonist in equine in vitro models and in an in vivo acute synovitis model in Shetland ponies. Read the full article here
Read moreNew publication: Isolation and tracing of matrix-producing notochordal and chondrocyte cells using ACAN-2A-mScarlet reporter human iPSC lines
A massive congrats to Xiaole Tong and the team for this amazing collaborative effort! Read the full paper in Science Advances here >>
Read moreNew publication: Outcome One Year after Acetabular Rim Extension Using a Customized Titanium Implant for Treating Hip Dysplasia in Dogs.
A new publication by Irin Kwananocha is out now! Read here >>
Read moreNew publication: Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment
A new publication by Laagland et al. is online! Congrats Lisanne on your work unveiling signalling pathways of notochordal cell-derived matrix! Read paper >>
Read moreNew publication: A combined western and bead-based multiplex platform to characterize extracellular vesicles
Congrats to Josette van Maanen on her paper in Tissue Engineering: part C which describes the evaluation of a combined western and bead-based multiplex platform (DigiWest) for the capacity to simultaneously detect multiple EV markers in low-protein samples. Read the full paper here >>
Read moreNew publication: Responsible innovation in stem cell research: using responsibility as a strategy
Marianna Tryfonidou and Lizette Utomo contributed to a bioethics paper by Assen et al. on the concept of responsibility in stem cell research. The paper illustrates how this concept could inform strategies to deal effectively with the ethical implications of stem cell research. Read the paper >>
Read moreNew publication: The catabolic-to-anabolic shift seen in the canine osteoarthritic cartilage treated with knee joint distraction occurs after the distraction period
New publication by Teunissen, et al. in Journal of Orthopaedic Translation on the changes in cartilage physiology after knee joint distraction. Read paper >>
Read moreNew publication: Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients
New paper bij Tellegen, et al. in Osteoarthritis and Cartilage on a microsphere formulation for the controlled delivery of celecoxib to combat pain in osteoarthritis. Read the paper >>
Read moreNew publication: Synovial membrane-derived mesenchymal progenitor cells from osteoarthritic joints in dogs possess lower chondrogenic-, and higher osteogenic capacity compared to normal joints
A new publication by Teunissen, et al. published in Stem Cells Research & Therapy provides insights in the differentiation capacity of mesenchymal progrenitor cells derived from canine OA synovial membrane. Congrats to Michelle for this wonderful publication! Read the full paper here >>
Read moreNew publication: Hyperosmolar expansion medium improves nucleus pulposus cell phenotype
New paper by Laagland et al in JOR Spine shows the beneficiary effects of hyperosmolarity on in vitro expansion of canine NP cells. Congrats to Lisanne for this wonderful publication! Read the paper >>
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