A massive congratulations to Daniele and his supervisory team (Chantal, Marianna, and Marca Wauben) for publishing his first peer-reviewed paper! The paper reviews the current state of research on EVs as cell-free therapy for IVD degeneration and emphasizes the importance of applying the MISEV guidelines for the isolation, characterization, and functional testing of EVs in…

A wonderful gift before the end of the year for the iPSpine team! The latest work is published in Biomaterials, and presents a novel approach to intervertebral disc regeneration. This study combines iPSC technology with the unique regenerative potential of notochordal cells delivered through an advanced hydrogel system, hereby taking an important translational step towards…

Congrats to Lisanne Laagland and colleagues for their latest paper where they explored an alternative for notochordal cells using human induced pluripotent stem cells (iPSC) by comparing cells derived from disc progenitor cells versus blood cells. By combining these cells with an instructive disc-derived matrix, the team achieved better differentiation into healthy, disc-repairing cells. The…

A huge congratulations to PhD candidate Amir Kamali on his first published manuscript! Excitingly, this study is the first to document the presence of High Intensity Zones (HIZ) on both MRI and histology at the lumbosacral level in dogs with disc degeneration. This remarkable finding further strengthens the growing similarities between dog and human MRI…

Congrats to Ann-Sofie Scheike who published her paper on the effects of a glucagon-like peptide 1 receptor agonist in equine in vitro models and in an in vivo acute synovitis model in Shetland ponies. Read the full article here

A massive congrats to Xiaole Tong and the team for this amazing collaborative effort! Read the full paper in Science Advances here >>

A new publication by Irin Kwananocha is out now! Read here >>

A new publication by Laagland et al. is online! Congrats Lisanne on your work unveiling signalling pathways of notochordal cell-derived matrix! Read paper >>

Congrats to Josette van Maanen on her paper in Tissue Engineering: part C which describes the evaluation of a combined western and bead-based multiplex platform (DigiWest) for the capacity to simultaneously detect multiple EV markers in low-protein samples. Read the full paper here >>

Marianna Tryfonidou and Lizette Utomo contributed to a bioethics paper by Assen et al. on the concept of responsibility in stem cell research. The paper illustrates how this concept could inform strategies to deal effectively with the ethical implications of stem cell research. Read the paper >>

New publication by Teunissen, et al. in Journal of Orthopaedic Translation on the changes in cartilage physiology after knee joint distraction. Read paper >>

New paper bij Tellegen, et al. in Osteoarthritis and Cartilage on a microsphere formulation for the controlled delivery of celecoxib to combat pain in osteoarthritis. Read the paper >>

A new publication by Teunissen, et al. published in Stem Cells Research & Therapy provides insights in the differentiation capacity of mesenchymal progrenitor cells derived from canine OA synovial membrane. Congrats to Michelle for this wonderful publication! Read the full paper here >>

New paper by Laagland et al in JOR Spine shows the beneficiary effects of hyperosmolarity on in vitro expansion of canine NP cells. Congrats to Lisanne for this wonderful publication! Read the paper >>